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Selank Peptide | TP 7 Peptide | CAS 129954-34-3: For RUO
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- Scientific Definition
- Common Research Applications
- Synonyms
- Product Specifications
- Quality & Testing
- Referenced Citations
- Behind The Peptide
- Glossary
Mechanism of Action
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from tuftsin, an endogenous immunomodulatory peptide. It has been studied for its interaction with GABAergic signaling pathways, modulation of enkephalin-degrading enzymes, and influence on cytokine and gene expression profiles within central nervous system models.
These effects together may underlie observed anxiolytic-like and stress-regulatory properties without classic benzodiazepine sedation profiles.
In peer-reviewed and experimental literature, Selank peptide has been explored for use in:
- Anxiolytic pathway research
- GABAergic neurotransmission studies
- Neuroimmune signaling models
- Stress-response modulation research
- Gene-expression profiling in CNS tissues
- Peptide-based nootropic research frameworks
Important RUO Notice
These applications describe published research contexts only.
The Selank peptide offered on this site is supplied exclusively for laboratory investigation.
- Selank
- Selank peptide
- TP 7 or TP-7
- TP 7 peptide
- Tuftsin analoG
- CAS: 129954-34-3
- PL14736 (research designation)
- Selanc / Slank (alternate spellings in literature)
Available Forms
- Product Name: Selank (TP 7)
- Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
- Amino Acid Length: 7 amino acids
- Molecular Formula: C₃₃H₅₇N₁₁O₉
- Molecular Weight: ~751.8 Da
- Peptide Class: Synthetic heptapeptide (tuftsin analog)
- Format: Lyophilized powder
- Salt Form: Acetate (when applicable)
- Purity: ≥99% (HPLC-verified)
- Grade: Research-grade (RUO)
- Solubility: Water or buffered solutions (research handling only)
Use Limitation:
Selank peptide is intended solely for laboratory research use.
As a trusted supplier of pure selank, all batches are manufactured under controlled conditions appropriate for RUO peptides.
Each lot includes:
- Stability Guaranteed: Lot tracking and stability testing supported by -20°C cold-chain storage to protect formulation integrity.
- Certificate of Analysis (Batch-specific COA: See here) – each bottle contains a QR code verifying quality & testing
- Purity: ≥98% verified by third-party HPLC
- Identity: confirmed via mass spectrometry
- Endotoxin, sterility, and heavy-metal screening
- Vertical Integration: Complete oversight and traceability from initial synthesis to final packaging and shipment.
Dergunova, L. V., Filippenkov, I. B., Limborska, S. A., & Myasoedov, N. F. (2021). Pharmacotranscriptomics of peptide drugs with neuroprotective properties. Medical Research Reviews, 41(2), 754–769. doi.org/10.1002/med.21704
Kolomin, T. A., Levitskaya, N. G., & Filippenkov, I. B. (2023). Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Journal of Experimental and Clinical Pharmacology, 2(4), 1–10. https://pubmed.ncbi.nlm.nih.gov/21609736
Medvedev, V. E., Tereshchenko, O. N., Kost, N. V., Ter-Israelyan, A. Y., Gushanskaya, E. V., Chobanu, I. K., Sokolov, O. Y., & Myasoedov, N. F. (2015). Optimization of the treatment of anxiety disorders with selank. Zhurnal Nevrologii i Psikhiiatrii imeni S.S. Korsakova, 115(6), 33–40. PMID:26356395. https://pubmed.ncbi.nlm.nih.gov/26356395
Zozulia, A. A., Neznamov, G. G., Siuniakov, T. S., Kost, N. V., Gabaeva, M. V., Sokolov, O. Iu., Serebriakova, E. V., Siranchieva, O. A., Andriushenko, A. V., Telesheva, E. S., Siuniakov, S. A., Smulevich, A. B., Miasoedov, N. F., & Seredenin, S. B. (2008). Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. https://pubmed.ncbi.nlm.nih.gov/18454096
Zozulya, A. A., Meshavkin, V. K., Toropov, A. V., & Kost, N. V. (2001). Semax and Selank inhibit the enkephalin-degrading enzymes of human serum. Bulletin of Experimental Biology and Medicine, 131(4), 315–317. https://pubmed.ncbi.nlm.nih.gov/11443939/
- Selank was developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences by Vladimir Khavinson and Tatiana V. Voronina, adapting the immune peptide tuftsin to study brain–immune signaling.
- It’s often studied via nasal delivery to explore direct brain access without relying heavily on systemic circulation.
- Unlike classic anxiety drugs, Selank is studied for modulating GABA signaling without acting as a direct receptor agonist.
- It was modified to be more stable than natural tuftsin, allowing longer activity in experimental conditions.
- GABA (Gamma-Aminobutyric Acid):A naturally occurring neurotransmitter in the brain that reduces neural activity, helping regulate calmness, prevent overstimulation, and maintain balance in the nervous system.
- GABAergic Signaling: A key brain communication system involving GABA, the primary inhibitory neurotransmitter, which helps regulate calmness, reduce overstimulation, and maintain neural balance under stress.
- Tuftsin: A naturally occurring peptide derived from immunoglobulin G (IgG) that plays a role in immune activation and served as the structural foundation for developing Selank.
- Cytokines: Small immune signaling proteins that coordinate inflammation and cellular responses, helping regulate how the body reacts to stress, infection, and tissue changes.
- Neuroimmune Interaction: The bidirectional communication between the nervous and immune systems, influencing mood, stress responses, inflammation, and overall physiological regulation.
Protected: Selank | TP 7 Peptide
Selank was developed in the 1990s at the Institute of Molecular Genetics of the Russian Academy of Sciences by Vladimir Khavinson and Tatiana V. Voronina, adapting the immune peptide tuftsin to study brain–immune signaling.
Each lot includes:
- Batch-specific COA with QR code verification
- Purity: ≥98% verified by third-party HPLC
- Identity: confirmed via mass spectrometry
- Endotoxin, sterility, and heavy-metal screening
- Full traceability from synthesis to shipment
- Stability Guaranteed: Lot tracking and stability testing supported
Not for human use. Not a drug. Not for diagnostic, therapeutic, or veterinary purposes.
Why Selank Research Matters
Neuroregulatory
Studied in relation to neural activity under stress-related conditions
Immunity
Explored in immune signaling and neurochemical interaction research
Inter-System
Examined across neurological and immunological signaling systems
Why Choose Alivara’s Selank
Transparency
Alivara’s peptides are accompanied by visible documentation- QR codes for verification will be included.
Verified Purity
Third-party HPLC and mass-spectrometry analyses verify identity and purity. We adhere to CGMP guidelines.
Education
Alivara Peptide Sciences offers educational context so researchers can understand each product.
Compliance
Your peace of mind. Built in FDA-registered, NSF-certified sites following strict CGMP and ISO standards.
Professionalism
Where passion meets precision. Formulae designed by a cross-disciplinary team of R&D and biochemistry experts.
Stability
Our systems are built in compliance with CGMP standards for long-term regulatory resilience.
Who Can Order Selank
TP 7 | Selank: FAQs
What is Selank?
Selank is a synthetic heptapeptide (TP 7) originally developed as an analog of the endogenous immunomodulatory peptide tuftsin. Structurally, it is known as Thr-Lys-Pro-Arg-Pro-Gly-Pro, and it is studied primarily in relation to the central nervous system, stress, and immunity in preclinical and clinical research settings.
What is selank peptide used for?
In published literature, Selank peptide may influence GABAergic signaling, modulate cytokine expression, and affect stress-response pathways.
Where to buy Selank?
For research purposes, Selank peptide should only be sourced from Research Use Only (RUO) suppliers providing verified purity and batch-specific COAs.
Can selank be prescribed?
Selank is not FDA-approved in the United States and therefore cannot be prescribed under U.S. regulatory frameworks. It has been approved for medical use in Russia under specific formulations, but outside those jurisdictions it is supplied only for research use.
Why is Selank not FDA approved?
Selank has not undergone the FDA drug-approval process, which requires extensive U.S.-based clinical trials demonstrating safety and efficacy for specific indications. Lack of FDA approval does not imply ineffectiveness—only that regulatory approval has not been pursued or completed under FDA standards.
How to Reconstitute Selank (Laboratory Context)?
In laboratory settings, Selank peptide is typically supplied as a lyophilized (freeze-dried) powder and must be dissolved before use in research applications.
To reconstitute, a measured volume of sterile diluent—commonly bacteriostatic water—is slowly added to the vial. The liquid is introduced gently along the inner wall of the vial (rather than directly onto the powder) to help preserve peptide integrity. The solution is then allowed to sit until fully dissolved; gentle swirling may be used, but shaking is generally avoided.
The final concentration depends on how much liquid is added.
How is Selank packaged and shipped to preserve laboratory integrity?
Shipments are prepared according to RUO handling standards and may include insulated packaging or cold-chain options depending on order size and destination. All packages are clearly labeled as Research Use Only and include batch-specific documentation such as Certificates of Analysis.
How Fast Is Selank Shipped After Ordering?
Orders for Selank are typically processed and shipped within 1–2 business days after order verification, depending on documentation review and inventory availability.
All peptides are manufactured in FDA-registered and NSF-certified facilities. CGMP (Current Good Manufacturing Practice) and ISO-aligned systems ensure clinical research-grade quality and consistency. Not for human or veterinary use.
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